How likely do cDNAs with start-loss variants appear in mRNA-seq?
0
0
Entering edit mode
6.4 years ago
John Ma ▴ 310

I know that many transcripts having frameshift mutations will be degraded by nonsense- or readthrough-mediated degradation, subject to rules that are well-known.

How how about start-loss? Most likely they won't be translated if they don't have an alternate start codon, but will they be degraded quick enough that they won't show up in RNAseq data?

RNA-Seq rna-seq • 943 views
ADD COMMENT

Login before adding your answer.

Traffic: 1404 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6