Transcription factors and closed/activated/repressed chromatin
0
0
Entering edit mode
6.3 years ago
salamandra ▴ 550

Is it possible for a TF to bind to closed chromatin without opening it? I mean, is it possible for chip-seq peaks of non-pioneer TFs to exist in closed chromatin?

If it is, can we assume that TF does not affect the gene expression of the corresponding gene?

Chromatin activation marks contributing to change in gene expression, like H3K4me3, show up in the sequence of the gene or are they in the TF binding site?

Do chromatin activation marks correspond to gene expression activation or does it just mean chromatin is available to bind TFs and depending if the TF is repressor or activator, gene expression decreases or increases?

Thanks in advance :)

ChIP-Seq chromatin ATAC-seq • 1.4k views
ADD COMMENT

Login before adding your answer.

Traffic: 2022 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6