I have two RNA isolation techniques (I1, I2) for a specific experiment that I would like to compare which one outputs a more reproducible sequencing data. I have three seperate rna seq runs using both isolation techniques, so three replicates each condition. What I had in my mind is to fit a dispersion curve either using voom or the estimate dispersion function of Deseq2 specific to each condition and see which curve lies on top of the other one. Does this approach makes sense? If not do you have any other suggestions? IS there a quantity that I can use to quantify dispersion a single number that I can get from the dispersion curve? Any help is appreciated.