Does a no-normal pipeline exist for MuSiC?

Question

[John Ma]

Hi,

We have a large set of tumor-only WES data that we want to run music smg. However, it's unclear from the documentations on whether:

1. Matched tumor-normal bam files are required for music smg per se,
2. Running music bmr calc-bmr is necessary before running music smg, and
3. I can use the output from music bmr calc-wig-covg instead of music bmr calc-covg as the input of music bmr calc-bmr.

I would like previous users to give us more insight on this. Thanks!

[Cyriac Kandoth]

hi. This has been answered at is needed info (BAM and MAF) files for normal tissues in MUSIC?