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Question: Simulating Trio Data
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gravatar for Ritu
2.5 years ago by
Ritu • 0
Ritu • 0 wrote:

Which tool could be used to generate/simulate parents-offspring whole genome sequences (human) in accordance with a specified recombination rate?
genome simulation trio • 509 views
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modified 2.5 years ago by Len Trigg • 1.5k • written 2.5 years ago by Ritu • 0
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gravatar for Len Trigg
2.5 years ago by
Len Trigg • 1.5k
New Zealand
Len Trigg • 1.5k wrote:

You could use the simulation tools available in RTG Tools. I would recommend running the demo-tools.sh script that comes as part of the package, as that steps through an end to end simulation of genomes of family members. You can then modify things from there according to your needs. In particular rtg childsim has the ability to adjust the overall recombination rate via --num-crossovers
ADD COMMENT • link written 2.5 years ago by Len Trigg • 1.5k

Thanks for the reference. I would try the tool's simulation.

ADD REPLY • link written 2.4 years ago by Ritu • 0
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