Question: Simulating Trio Data
0
gravatar for Ritu
18 months ago by
Ritu0
Ritu0 wrote:

Which tool could be used to generate/simulate parents-offspring whole genome sequences (human) in accordance with a specified recombination rate?

genome simulation trio • 376 views
ADD COMMENTlink modified 18 months ago by Len Trigg1.4k • written 18 months ago by Ritu0
0
gravatar for Len Trigg
18 months ago by
Len Trigg1.4k
New Zealand
Len Trigg1.4k wrote:

You could use the simulation tools available in RTG Tools. I would recommend running the demo-tools.sh script that comes as part of the package, as that steps through an end to end simulation of genomes of family members. You can then modify things from there according to your needs. In particular rtg childsim has the ability to adjust the overall recombination rate via --num-crossovers

ADD COMMENTlink written 18 months ago by Len Trigg1.4k

Thanks for the reference. I would try the tool's simulation.

ADD REPLYlink written 18 months ago by Ritu0
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