Question: Simulating Trio Data
gravatar for Ritu
2.5 years ago by
Ritu0 wrote:

Which tool could be used to generate/simulate parents-offspring whole genome sequences (human) in accordance with a specified recombination rate?

genome simulation trio • 509 views
ADD COMMENTlink modified 2.5 years ago by Len Trigg1.5k • written 2.5 years ago by Ritu0
gravatar for Len Trigg
2.5 years ago by
Len Trigg1.5k
New Zealand
Len Trigg1.5k wrote:

You could use the simulation tools available in RTG Tools. I would recommend running the script that comes as part of the package, as that steps through an end to end simulation of genomes of family members. You can then modify things from there according to your needs. In particular rtg childsim has the ability to adjust the overall recombination rate via --num-crossovers

ADD COMMENTlink written 2.5 years ago by Len Trigg1.5k

Thanks for the reference. I would try the tool's simulation.

ADD REPLYlink written 2.4 years ago by Ritu0
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