Entering edit mode
5.7 years ago
baggiohbs.1989
•
0
To use --score ScoreFile
function, in ScoreFile
, we need SNP ID, effect allele and effect size. Say, if the effect allele is the minor allele, then the score contributed by the SNP should be effective size * dosage (effect allele)
; however, if the effect allele is not the minor allele, then how to calculate the contribution of the SNP. It should be effect size * (2 - dosage (effect allele))
, or effect size * - dosage(effect allele)
?