I used clusterProfiler for KEGG pathway enrichment. Now I want to do crosstalk over them. I utilized jaccard coefficient in order to measure overlap between the pathways. But my problem is that from clusterProfiler I'm getting many irrelevant pathway enrichment too (my gene entries are for Asthma n getting kegg enrichment such as Prostate cancer (hsa05215)). So is there any database or method by which I can get 'biologically' relevant pathway crosstalk?
Thank you in advance!