Question: Meta-Analysis p-value combining and adjusting
1
gravatar for devikaparvathy
2.5 years ago by
India
devikaparvathy40 wrote:

I am conducting a meta-analysis from different RNA-Seq/Microarray datasets of the same hypothesis (Control vs a specific test condition, for example). While combining p-values from the multiple DEG experiments , should the raw p-values be used for combining and then adjusted or can the adjusted p-values be combined directly?

ADD COMMENTlink modified 2.5 years ago by mark.ziemann1.3k • written 2.5 years ago by devikaparvathy40
1
gravatar for mark.ziemann
2.5 years ago by
mark.ziemann1.3k
Australia/Mebourne/Geelong/Deakin
mark.ziemann1.3k wrote:

combine, then adjust.

Fisher's method has certain assumptions about what the p-value is that will almost certainly be violated if you do multiple-testing correction first.

Originally posted by Brent P

ADD COMMENTlink modified 2.5 years ago • written 2.5 years ago by mark.ziemann1.3k
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