Question: Epistasis in GWAS loci, examples?
1
gravatar for Floris Brenk
11 months ago by
Floris Brenk900
USA
Floris Brenk900 wrote:

Hi all,

I was been working on epistasis in a couple of GWAS loci. Basically the theory is that some GWAS loci might not work in an additive manner, but more in an epistasic way and calculated this using R :

Formula <- formula(paste("pheno ~ PC1 + PC2 + PC3 + PC4 + PC5 + SEX + SNP1 * SNP2"))

model_test <- glm(Formula, data = data, family = "binomial") 

summary(model_test)

Now I was wondering are there already "proven" robust epistasic associations out there that in any disease/trait between GWAS loci? Have been googling a bit but haven't really found anything, the majority of the papers out there are methods and theory papers..

R gwas epistasis • 309 views
ADD COMMENTlink modified 11 months ago • written 11 months ago by Floris Brenk900
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