to check allelic biases in histone peaks
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5.7 years ago
GK1610 ▴ 120

I have called QTLs on histone peaks if I want to see if hQTLs that are located inside the histone peaks exhibits allelic biases or not? How do I do it?

What I have done is as following:

1) I took peaks for which hQTLs-snps is inside the peak 2) for hQTL-snps, peaks combination, I found set of individuals which are het for those sites 3) I then plot histone peaks raw counts for those peaks and individuals. if the distribution is normally distributed then there is no bias as oppose if it shifted.

Am i right?

SNP ChIP-Seq • 837 views
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