Estimating cell sybtype methylation from EPIC /450K array

Question

[antgomo]

Hi all,

i am trying to estimate cell sub type methylation from EPIC array

I have the normalized betas and the cell composition de-convolution proportions from FlowSorted.Blood.EPIC package. My guess is to directly multiplying the selected proportion for that cell type by the methylation beta values for all CpGs for the selected sample for each cell type

I was looking in the literature and i didn't get anything clear, do you think if this approach is reliable?

Thanks in advance