Question: Differential Gene Expression Analysis From TMM normalized counts
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gravatar for boyinepallyki
8 months ago by
boyinepallyki0 wrote:

Hi,

I understand that DGE analysis software like EdgeR or DEseq take in raw counts as input and then calculated a normalized factor for TMM. The data set I have only has TMM normalized counts and I do not have access to the original counts. Is there a way to bypass EdgeR's internal normalization? Can I use these TMM values for differential expression analysis and if so, how?

Thank You

rna-seq • 346 views
ADD COMMENTlink written 8 months ago by boyinepallyki0
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