I would like to ask for meta-data to assess similarity of Interpro domains.
I have checked the ParentChildTreeFile.txt, the type description (repeat,domain,etc) (file: entry.list.tsv) and the gene ontology annotation (GO) for each domain. However I am not sure if this metadata are enough.
For example may a domain is a child of a parent domain in the ParentChildTreeFile but it has a distinct function to the parent. Also the GO annotation for domains is based on the GO annotation of proteins so the cellular component for a domain how much biological information contains? To this end, I would like to ask if there is any other knowledge for the interpro domains such a phylogenetic tree? In order to have the similarity of the domains.