13 months ago by
There are a number of third-party databases that provide information on the clinical impact of various types of short and gross germline mutations. Consider starting with HGMD, ClinVar, and/or OMIM. Information can be accessed via API or, in some cases, as databases, delimited files, or VCFs.
If you are specifically interested in somatic mutations, COSMIC or TCGA are good starting points. Be aware that somatic variant classification procedures are less characterized than those recommended for germline variant classification, especially in the clinical space. There are a number of factors to consider, e.g., tumor heterogeneity, mutational burden, algorithm performance, driver vs. passenger, etc.