I'm planning to sequence bacterial genomes using both Nanopore and Illumina platforms to get nearly complete and accurate genomes. After getting sequence data, I'm going to perform hybrid assembly (e.g. Unicycler) or long-read assembly followed by short-read polishing.
In this case, can I get some advantages by using high accuracy models (e.g. dna_r9.4.1_450bps_hac.cfg) for guppy basecalling? Or, would fast models (e.g. dna_r9.4.1_450bps_fast.cfg) be enough?
I'm testing the speed performance of guppy on my Ubuntu 18.04 machine equipped with GTX1660 (Cuda 10.1), and it seems that fast models are much faster than high accuracy models (>10X).