I would like to ask if there is a pathogenicity or deleteriousness score implemented in any tool, regarding the process of somatic variant annotation, that could be used specifically in the case of putative somatic insertions/deletions, derived from the analysis of WGS/WES cancer data ? And could be utilized in the sense of prioritization, but solely for INDELs ?
Based on an initial searching, I took a look for the CADD score included in the ANNOVAR database, but unfortunately is underlined that is primarily used for SNPs (https://doc-openbio.readthedocs.io/projects/annovar/en/latest/user-guide/filter/#cadd-annotations)
Any idea or suggestion from any experienced user would be grateful !!