Question: Genetic correlation with related individuals
gravatar for alesssia
10 months ago by
London, UK
alesssia570 wrote:

Dear all,

I am aiming at evaluating the genetic correlation among ~150 continuous traits measured in ~1100 twin pairs (~2200 individuals). I have already run GWASs for each trait (using an LMM as implemented in GEMMA), therefore, I have both the genetic data and the GWAS summary statistics.

I had a look at the literature, and LDSC seems a pretty popular approach. However, due to our small-ish sample size (N<5000) and the fact that GWASs were run using an LMM, LDSC cannot be used with our data.

Unfortunately, also approaches based on genetic data (e.g., GTCA, BOLT-REML) seem, to the best of my understanding, to be unsuitable, since they require unrelated individuals. I am aware that I could simply remove one twin from each pair, but I would avoid halving my sample size.

I am now wondering whether anyone is aware of any other approach that allows for related data, or whether anyone has any suggestion.

Many thanks in advance!

ADD COMMENTlink written 10 months ago by alesssia570
Please log in to add an answer.


Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 2141 users visited in the last hour