Question: Relationship between instantaneous rate of change and global clock model?

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Namenlos •

**0**wrote:What is the relationship between the instantaneous rate of change in the rate matrix of continuous time Markov chain and the branch rate/clock rate in a global/strick clock model? For instance, in an F81 or GTR model of nucleotide substitution, should the individual instantaneous rates of change (e.g., A -> C, T -> C, etc.) sum up to the global clock rate?