Question: How to normalize between samples in WGS metagenomics
0
gravatar for plicht
5 months ago by
plicht0
plicht0 wrote:

Hello,

There is a big and increasing number of methods used for between sample normalization in whole genome metagenomics and yet no consensus which to apply Normalization Methods. Rarefaction is not a very suitable choice IMHO.

Do you have experience with that? If sequencing depth does not vary greatly (lets say at most factor 3), would it be an option to just not apply normalization at all?

ADD COMMENTlink modified 5 months ago • written 5 months ago by plicht0
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