Count analysis framework for DNA encoded libraries?

Question

[johannesdolberg]

Hi,

Analysis of DNA encoded libraries (DELs) overlaps to some extend with DE analysis: * Counts data * Heteroscedasticity / overdispersion * Next gen sequencing / comparable sequencing depth * Often few samples per condition

However, DELs can be of the size 10E8 fragment combinations (genes equivalent) or bigger. For such cases sample size differ compared to DE.

For some analysis you end up having a large amount of fragment combinations in one condition, which, due to the sampling, is not found in another. For this reason any assumptions about most fragment combinations not being DE doesn't hold.

Here comes the question: For the above-mentioned case, do you think any of the RNA-seq frameworks could be a match?

Best regards, Johannes