For my analysis I need to simulate synthetic samples for my vcf file.
I have a genome-wide vcf file for 100 samples (patients) and want to add more samples (with genotypes, AF etc) to it as if they were drawn from the same distribution. I'm working on association testings and polygenic risk scores and the problem that I'm facing is, that my sample size is too small. So I'd like to apply my models to a larger sample size.
I do not want to add more variants.
Best regards and thanks in advance, Thomas