I need to analyze the survival of LUAD TCGA patients depending on the level of expression of a gene set (signature?). I have more than 30 genes for that.
I found this Survival analysis of TCGA patients integrating gene expression (RNASeq) data tutorial. But that is for one gene and KMplot is based on gene alteration rather than low vs high expression. I also used cBioPortal to plot survival for each gene.
I suspect that I need to look at my question as an ANOVA problem. Some genes will add significance to the set and some will not.
So, in the end, I would like to have a set of genes which combination will significantly change the survival of LUAD patients. Are there any readily available maybe web-based tools for that? if not, I will appreciate any advice on how to structure algorithm for my problemband using existing R packages for survival analysis or basically anything