Question: Mixed Illumina Methylation data from EPIC and 450k
gravatar for Pac314
12 weeks ago by
Pac3140 wrote:

I am analyzing some mixed methylation array data from EPIC and 450k arrays using Minfi and would like to know whether the two arrays can be combined using combineArray() function prior to initial QC and normalization. Please could you advise me on how to combine the array data without compromising downstream analysis.

ADD COMMENTlink modified 24 days ago by Biostar ♦♦ 20 • written 12 weeks ago by Pac3140

Hey, did you figure out how to do this? :)

I was also thinking about performing QC and normalization and separately and then combining, however, this paper shows how they performed normalization together for both arrays as they had prepared a virtual array.

Looking forward to your reply!

ADD REPLYlink written 1 day ago by godboleshweta950
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