Question: Convert Fdr Control Q-Value To P-Value
2
gravatar for J.F.Jiang
6.7 years ago by
J.F.Jiang750
China
J.F.Jiang750 wrote:

Hi everyone,

I have downloaded a set of processed data of gene expression relationship, while they offered a result of q value. Since I want to use the p value to adjust the next step, how can I convert this Q value to p value?

Thanks!

• 4.0k views
ADD COMMENTlink modified 6.3 years ago by admiral.david0 • written 6.7 years ago by J.F.Jiang750

Is it possible that your dataset was analyzed by a method that does not produce p-values? For example, baySeq, a tool for testing differential expression in RNA-Seq data, produces posterior probabilities from a Bayesian analysis and calculates FDR directly from them. The nature of the calculations is such that no p-value is involved.

ADD REPLYlink written 6.7 years ago by Ryan Thompson3.4k

How did you get your Q values ?

ADD REPLYlink written 6.7 years ago by ff.cc.cc1.3k
1
gravatar for David Quigley
6.7 years ago by
David Quigley11k
San Francisco
David Quigley11k wrote:

I think the short answer is that you can't. One way to calculate a Q value estimate is from a distribution of P values (e.g. the way Storey's qvalue works), but I don't think there is any way to reconstruct the P value distribution from a set of estimated Q values. You should calculating the P values directly if that's what you want. The manual to the qvalue package has more information about what a Q value is and how it can be calculated, which you might want to read.

ADD COMMENTlink written 6.7 years ago by David Quigley11k

YES, I have read the wiki of Q value and methods of original author, I can not convert this Q, but I can still estimate the p-value

ADD REPLYlink written 6.7 years ago by J.F.Jiang750
Please log in to add an answer.

Help
Access

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 944 users visited in the last hour