Residue Co-Evolution With Few Sequences

Question

[miquelduranfrigola]

Hi all,

I'm trying to do a residue-residue coevolution analysis of a protein family that only has ~100 proteins in Pfam. My final goal is to predict residue-residue contacts.

The best methods (e.g. DCA and PSICOV) require >1,000 sequences... are you guys aware of an alternative?

Thanks!

Answer 1

[Whetting]

check this paper: "emerging methods in protein co-evolution" Nature reviews Genetics Volume 14, april 2013