I am not sure if the following would even make sense....
Tissues are composed of composite cell types, and often there are studies such as microarray/NGS where we perform a collective sampling of cells from these tissues. Information about the composition (say percentage of cell type) is not taken into consideration. In some case (such as brain/cancer), there are many studies where specific cell type specific marker genes are identified.
I was wondering if there are any methods, where we can use these cell type marker gene expression from RNA-Seq, to estimate the percentage composition of the individual cells in tissue (or say differential percentage)... Do you even think this method would make sense...?
If there are any references towards this line of thought, pls do share?