Forum:CADD Error in EXOMISER
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Entering edit mode
12 weeks ago
shwetan • 0

I have downloaded the gnomad.genomes.r3.0.indel.tsv and gnomad.genomes.r3.0.indel.tsv.gz.tbi in my examiner folder and I gave the path in applications.properties as examiner-cli-12.1.0/data/2102_hg38/gnomad.genomes.r3.0.indel.tsv and both files are present in that data folder and I have made changes in iml file also but still I am getting the below error.

Exception encountered during context initialization - cancelling refresh attempt: org.springframework.beans.factory.UnsatisfiedDependencyException: Error creating bean with name 'exomiserCommandLineRunner': Unsatisfied dependency expressed through field 'analysisParser'; nested exception is org.springframework.beans.factory.UnsatisfiedDependencyException: Error creating bean with name 'analysisParser' defined in URL [jar:file:/Users/admin/Desktop/exomiser-cli-12.1.0/lib/exomiser-core-12.1.0.jar!/org/monarchinitiative/exomiser/core/analysis/AnalysisParser.class]: Unsatisfied dependency expressed through constructor parameter 0; nested exception is org.springframework.beans.factory.UnsatisfiedDependencyException: Error creating bean with name 'genomeAnalysisServiceProvider' defined in class path resource [org/monarchinitiative/exomiser/autoconfigure/genome/GenomeAnalysisServiceAutoConfiguration.class]: Unsatisfied dependency expressed through method 'genomeAnalysisServiceProvider' parameter 0; nested exception is org.springframework.beans.factory.BeanCreationException: Error creating bean with name 'org.monarchinitiative.exomiser.autoconfigure.genome.Hg38GenomeAnalysisServiceAutoConfiguration': Bean instantiation via constructor failed; nested exception is org.springframework.beans.BeanInstantiationException: Failed to instantiate [org.monarchinitiative.exomiser.autoconfigure.genome.Hg38GenomeAnalysisServiceAutoConfiguration$$EnhancerBySpringCGLIB$$408163f2]: Constructor threw exception; nested exception is org.monarchinitiative.exomiser.autoconfigure.ExomiserAutoConfigurationException: Failed to load/find file /Users/admin/Desktop/exomiser-cli-12.1.0/data/2102_hg38/exomiser-cli-12.1.0/data/2102_hg38/gnomad.genomes.r3.0.indel.tsv. Please check exomiser properties file points to a valid tabix .gz file. 2021-04-23 16:06:33.460 INFO 1628 --- [ main] ConditionEvaluationReportLoggingListener :

Error starting ApplicationContext. To display the conditions report re-run your application with 'debug' enabled. 2021-04-23 16:06:33.463 ERROR 1628 --- [ main] o.s.boot.SpringApplication : Application run failed

Help would be appreciated Thank you in advance

exomiser cadd • 132 views
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