adjusted p-values in meta-analysis
0
0
Entering edit mode
10 weeks ago

Hi, I'm trying to do a meta-analysis of 4 studies (microarrays and RNA-seq). I'm using the rma function from the metafor package, with the DerSimonian-Laird (DL) method. If I want to identify differentially expressed genes, do I have to calculate the adjusted p-values from the p- values I have obtained? Do you think DL is a suitable method? Thank you so much for your help!

meta-analysis adj pvalue • 219 views
ADD COMMENT
1
Entering edit mode

I have doubt that the metafor is the right package to use for this kind of job unless you want to do things from the scratch. Anyway, for gene expression meta-analysis there are a number of packages and approaches. Check this link for an updated review of the different approaches.

ADD REPLY
0
Entering edit mode

Thank you very much for your time and help! I will take a look at the other packages (although in principle metafor is the package used by my group, so I just wanted to know if there was a more suitable method than DL). As for the p-value, it is still not clear to me if it is necessary to adjust it after the meta-analysis or not. Sorry for the inconvenience and thank you so much again.

ADD REPLY

Login before adding your answer.

Traffic: 1322 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6