I have downloaded metabric data from cbioportal. The folder contains files as follows:
1. data_expression_median.txt 2. data_mRNA_median_all_sample_Zscores.txt 3. data_mRNA_median_Zscores.txt
Which file should I consider for differential expression (DE) analysis. Since Deseq2 and EdgeR requires input as raw_counts, the above files are not useful to perform DE analysis.
Please suggest me the possible methods to perform DE analysis on this dataset.