Copy Number to Log2_ratio for autosomal
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Entering edit mode
11 weeks ago
afollette • 0

Hi,

I want to transform some ASCAT data into log2_r values. The file contains at total copy number column. I would then take fold ratio of the total copy number versus the natural ploidy, correct? Can I assume the natural ploidy for all autosomal regions are 2?

Thanks!

gdc cna cnv autosomal • 199 views
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Entering edit mode
10 weeks ago
Zhenyu Zhang ▴ 450

I am confused on what you want to do. If you want to compare to diploid of 2, why don't use the ASCAT copy number directly? I missed the point of log2 transformation and what you expect to gain from this.

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