Copy Number to Log2_ratio for autosomal

Question

[afollette]

Hi,

I want to transform some ASCAT data into log2_r values. The file contains at total copy number column. I would then take fold ratio of the total copy number versus the natural ploidy, correct? Can I assume the natural ploidy for all autosomal regions are 2?

Thanks!

Answer 1

[Zhenyu Zhang]

I am confused on what you want to do. If you want to compare to diploid of 2, why don't use the ASCAT copy number directly? I missed the point of log2 transformation and what you expect to gain from this.