How to get started with analyzing Genotype data from microarray?
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2.5 years ago

I'm pretty noob in Bioinformatics

I have downloaded a matching Expression (RNA-seq) and Genotype (microarray) data with the aim to call eQTL using the downloaded data.

I kinda get the RNA-seq data analysis part, But....

I'm totally not experienced when it comes to analysing Genotype data: I have hundreds of idat files, I guess this is the raw data file capturing the fluorescent of the probes or something?

Anyway, there are too many questions since I basically have close to zero knowledge of how to process this dataset, my question is:

  • Do you guys know of any resources or books that I can read to jumpstart my knowledge of how to process the genotype data? I have tried reading review papers but they usually focus on one aspect of the workflow and since I have zero knowledge I don't know how to contextualize them.

I'm looking for some practical guides, maybe a book? or a comprehensive blog? Maybe something similar to the book "RNA-seq Data Analysis: A Practical Approach" (which helps me tremendously when it comes to RNA-seq data analysis) but for genotype or array data?

Thank you!!

Genotype Illumina eQTL Microarray Array • 414 views
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