Apologies if this is a simple question, but I was trying to find a centralized biological knowledge graph (ie. connecting genes/proteins/actions/lipids/diseases, etc.) but I couldn't seem to find one. There are a number of databases listed in several reviews (https://www.sciencedirect.com/science/article/pii/S2001037020302804), though I was wondering why they are all disparate and why there isn't a centralized database for all information?
I don't think that all the complexity of biological knowledge could ever be fully summarized in one graph/network, especially if we consider all living organisms... In addition, multiple smaller databases are often more useful than a big one because each look at the data from a different angle and allow to explore different questions.
Nevertheless, efforts have been made to unify a significant part of the body of biological knowledge, the most official/authoritative being made by the gene onthology consortium:
The mission of the GO Consortium is to develop a comprehensive,
computational model of biological systems, ranging from the molecular
to the organism level, across the multiplicity of species in the tree
of life. [it consists in the] network of biological classes describing the current best representation of the “universe” of biology: the molecular functions, cellular locations, and processes gene products may carry out.