Is there a way to distinguish doublets from phagocytes performing efferocytosis in scRNA-seq data?
Entering edit mode
7 months ago

Hello everyone!

Here is an interesting conundrum. It has been reported that phagocytes may contain so-called “passenger” transcripts that originate from engulfed apoptotic cells, which not only obscures the transcriptional profile of a true phagocyte but also in certain cases may result in a combination of two distinct transcriptional profiles reminiscent of a neotypic doublet/multiplet. My question is how could one possibly distinguish such two types of events, given that the end result is the same – a mixture of two gene expression profiles?

scrna-seq • 200 views

Login before adding your answer.

Traffic: 1990 users visited in the last hour
Help About
Access RSS

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6