Guideline on phenotype transformation before GWAS?
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5 months ago
j.homann • 0

Hey guys. We are doing GWAS for almost 100 different phenotypes. These are distributed differently after looking at histograms and density. Most are normally or log-normally distributed and in the second case we would transform them with a log transformation and then analyze them.

In some cases, however, it is difficult to judge visually whether a transformation is appropriate, and if so, which one. We wonder if there is not a guideline in a good journal that addresses exactly this problem and could help us.

There is a lot on this in forums, but we would like to read a scientific guide on this topic. Maybe someone here knows something like that and can link the paper!

With best regards Jan

phenotype association GWAS study transformation • 130 views

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