Hi! I'm recently working on Infinium MethylationEPIC data for eQTM analysis. When I tried to map the Cis-Methylation site to Gene, I met a problem. Since I have Gene expression data aligned to hg38 reference, So I need also find the methylation probe location under hg38. I downloaded a manifest file from Illumina support page:(https://support.illumina.com/downloads/infinium-methylationepic-v1-0-product-files.html)
Infinium MethylationEPIC v1.0 B5 Manifest File (CSV Format)
And it has the annotation information for all the probes under hg37 and hg38
But for hg38, each probe has a start_location and end_location, with 3 bp long which is weird. So Can anyone help me with why the new annotation for each probe is 3 bp long, shall I use the mid?