Hi Everyone, I am a bit confused about the difference between Gibbs Sampling and Bootstrapping when it comes to Salmon and how these procedures affect downstream analysis. For context, I am trying to do analysis of 49 matched cancer vs. normal RNAseq samples in the context of alternative splicing (i.e. I am trying to cluster together patients with similar alternative splicing profiles and then see what genes are driving the clustering). I read the bootstrapping and Gibbs sampling improve transcript quantification for downstream analysis, but I am unsure how dramatic this effect may be for my purpose. Any advice or help in this regard would be appreciated!