Finding a list of heritable traits using GCTA
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22 months ago
samuelandjw ▴ 250

Suppose I have a list of traits, and I want to know which traits are heritable (not sure if this is a well-defined question ...) using GCTA GREML. For heritable traits, I want to know the exact magnitude of the heritability. Now, should I

  1. Test for $h_g^2$=0 using unconstrained ($h_g^2$ could be negative) GREML for each trait.
  2. For each significant trait (not sure if multiple testing is appropriate here), re-run constrained GREML to obtain the estimate of $h_g^2$.

Or

  1. Run constrained GREML and declare traits with significant p values or $h_g^2$ larger than a preset threshold as "heritable".

Which method is correct?

complex heritability traits GCTA • 310 views
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