How many SNPs are needed to perform haplotype analysis on siblings and their mother?
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18 months ago

Hello,

I'm hoping to get SNP array data from a handful of siblings as well as their mother (father is gone, sadly), to ultimately get phased genotypes/haplotypes of one of the siblings to see where a particular SNV in this specific sibling might have come from, and whether it's significant or inconsequential.

I know this can be done with STRs/microsatellites, as they are highly polymorphic. But is it possible with SNPs? How many SNPs are there in a 1Mbp window? Enough to tell siblings apart from each other? From their mother?

Please excuse my ignorance, this is my first time asking these types of questions.

Thank you!

haplotype linkage SNP pedigree • 282 views
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