Entering edit mode
2.7 years ago
kmeng
•
0
I have a single cell expression matrix and a set of transcription factor-target interactions. I want to test if the expression correlations between actual transcription factor-target interactions are greater than 10000 random off target links (so a transcription factor to a non-target). My gut says to use a 2-sample t-test or wilcoxon test to compare the sets of correlations, but I feel like there could be an independence violation due to some of the correlations being computed with the same genes both within each set and between sets. Any guidance on how to do this comparison?
