Protein CD45 has many isoforms in particular CD45RA and CD45RO. It is known: Naive T lymphocytes are typically positive for CD45RA, which includes only the A protein region. Activated and memory T lymphocytes express CD45RO, the shortest CD45 isoform, which lacks all three of the A, B, and C regions. This shortest isoform facilitates T cell activation. (Wikipedia).
Question: are there any known mechanisms which control splicing and switching from CD45RA to CD45RO production ? Can the be seen by expression data like single cell CITE-seq ?
PS
Some CITE-seq data suggests protein levels of CD45RA and CD45RO are ANTI-correlated (-0.5), and both very low correlated with its own RNA CD45 (See https://www.kaggle.com/alexandervc/cite-seq-cd53-vs-cd45-correlation )
