calculation of calibration factors using impuation reference panel and ethnicity
0
0
Entering edit mode
15 months ago

I am facing trouble in calculating the calibration factor using minor allele frequency in R.

The research paper related to this calculation is; https://www.nature.com/articles/nprot.2014.071 . It has the formula for calculating the calibration factor but i dont understand how to use it.

Could anyone please let me know that how should i write a script so that i will get the calibration factor of my GWAS summary statistics. Do i have to use average minor allele frequency from the summary statistics? I am following the paper whose link i pasted above. There is a calibration factor for other reference panels in that paper but i need to calculate the calibration factor for TOPMED reference imputation panel. Please help me in this regard.

Thanking you in advance.

GWAS Calibration factor • 252 views
ADD COMMENT

Login before adding your answer.

Traffic: 1841 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6