Positive or negative miRNA interaction
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12 months ago

Hi everyone, I'm exploring the TarbBase tool with multimir R package. I'm trying to download the validated target of some specific miRNAs I'm interested in but I see that the result of my research returns some targets whose "source type" is set as "positive" whereas others are set to "negative". I'm looking for all the direct targets of these miRNAs, that are supposed to be downregulated. Please can anyone clarify to me what do positive and negative miRNA interactions mean? Also in the TarBase you can see that for a specific miRNA target there are some positive/negative/unknown interactions validated (see the help section here1)

What type of interaction should I choose? Thank you so much

interactions mirna • 269 views

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