Creating CIBERSORTx signature matrix

Question

[FrankStarling]

Hi all, I want to acknowledge that there are several discussions on Biostars regarding how to build a signature matrix or how to normalize datasets for CIBERSORTx. Nevertheless I would still appreciate some clarification on what I am trying to acheive.

I am trying to build a signature matrix from the single cell data matrix file found on this GEO database page (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE157640). Below is a screenshot of what the data look like.

I would greatly appreciate if someone could point me in the right direction.