Filtering of mCs before downstream DMR analysis

Question

[poa.alpina]

Hi,

I am working with a WGBS dataset and have done alignment and methylation calling with Bismark and DMR analysis with metilene.

So far I have only filtered on read depth before DMR calling, but I was wondering if it is necessary to perform some test (binomial e.g.) to identify true mCs before DMR calling?