Cluster/group samples based on scRNA data

Question

[Patrick]

Hi all,

I have ~50 samples with each being profilied by scRNA. By UMAP of each individual sample, I can clearly see 3-4 distinct patterns among these samples. Now what is the appropriate way for me to group these samples according to their similarity to each other based on scRNA data? The desired output plots could be something like dendrogram of hierarchical clustering, correlation matrix, etc.

Thank you.

Patrick

Answer 1

[ATpoint]

I recommend going through https://bioconductor.org/books/release/OSCA.basic/clustering.html to get the basics of scRNA-seq going.