should I normalized the relative abundance of TILs data?

Question

[ali]

hi everyone I downloaded the relative abundance of TILs of COAD cancer. the relative of 28 immune cells was reported like ; TCGA.3L.AA1B.01 TCGA.4N.A93T.01 Act_CD8 -0.235708222 -0.230320602 Tcm_CD8 0.319737955 -0.346063646 Tem_CD8 0.216558038 -0.519660955

Should I perform data normalization before conducting differential analysis on immune cell populations when working with the downloaded data of relative immune cell abundances in COAD cancer? thanks