CNVkit analysis with different average depths of control normals

Question

[luna]

Hello. I would like to use CNVkit to detect SCNAs in tumor samples.

I have several matched normal samples that were sequenced in the same way as the tumor samples, except for the average depth. For example, the matched normal samples have an average depth of 100x, while the tumor samples have an average depth of 500x. Since the average depth is different, can I still create a pooled reference using these normal samples and use it to detect CNVs in the tumor samples?

Thank you.