WGCNA Dendrogram Branch missing from modules
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11 weeks ago
mhale • 0

Hi all,

Currently using hdWGCNA for network construction in a scRNAseq dataset, and I keep identifying branches on the cluster dendrogram that look robust in terms of dissimilarity, but that fail to be assigned as modules. Figure attached. The branches in question are the two that reach ~0.65 and 0.75 on the y-axis, to the right of the 'yellow' module branch. Adjusting minModuleSize has no effect.

Has anyone encountered this issue of 'missing' modules before?

enter image description here

WGCNA dendrogram hdWGCNA • 300 views
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I am not familiar with hdWGCNA but perhaps some modules are excluded because their genes are not expressed in a certain proportion of cells.

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