Training a Mini Calico/Borzoi Model using cardiomyocyte RNA-Seq, ATAC-Seq, and WGBS

Question

[Cameron.walker9900]

Greetings,

Do any of you have experience with training Calico/Borzoi mini model. The github repo provides model weights for different mini models, but does not provide any information on how to train your own. I have a large data set of bulk RNA-seq, ATAC-Seq, and WGBS from cardiomyocytes at different time points post perturbation. The goal is to use the Borzoi mini model to identify regulatory motifs that might play a role in the perturbation response.

Calico/Borzoi: https://github.com/calico/borzoi

I am open to any suggestions.

Thanks!