Downstream analysis for CIBERSORTx imputed cell-specific gene expression

Question

[Fred Lawrence]

Hi, everyone! I was wondering if I could use limma for differential gene expression of the cell-specific values imputed by CIBERSORTx and what downstream analysis is permitted with these data. I was thinking of using limma since my input data is a microarray expression matrix from Illumina HumantHT-12 v.4 expression bead chip (background corrected and quantile normalized). The sample came from whole blood and used the LM22 signature for imputation. Feel free to comment on my workflow. Thank you!